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Synthesis, Characterisation and 3D Printing of an Isosorbide Based, Light Curable, Degradable Polymer for Potential Application in Maxillofacial Reconstruction

Owji, N; Aldaadaa, A; Cha, J-R; Shakouri, T; Garcia, E; Kim, H-W; Knowles, JC; (2020) Synthesis, Characterisation and 3D Printing of an Isosorbide Based, Light Curable, Degradable Polymer for Potential Application in Maxillofacial Reconstruction. ACS Biomaterials Science & Engineering , 6 (5) pp. 2578-2587. 10.1021/acsbiomaterials.9b00884. Green open access

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Abstract

Although emergence of bone tissue engineering techniques has revolutionised the field of maxillofacial reconstruction, the successful translation of such products, especially concerning larger sized defects, still remains a significant challenge. Light curable methacrylate based polymers have ideal properties for bone repair. These materials are also suitable for 3D printing which can be applicable for restoration of both function and aesthetics. The main objective of this research was to synthesise a mechanically stable and biologically functional polymer for reconstruction of complex craniofacial defects. The experimental work initially involved synthesis of (((3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diyl)bis(oxy))bis(ethane-2,1-diyl) bis((4-methyl-3-oxopent-4-en-1-yl)carbamate), CSMA-1, and ((((((((((((3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diyl)bis(oxy))bis(ethane-2,1 diyl))bis(oxy))bis(carbonyl))bis(azanediyl))bis(methylene))bis(3,3,5-trimethylcyclohexane-5,1-diyl))bis(azanediyl))bis(carbonyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate), CSMA-2; Nuclear Magnetic Resonance (NMR) analysis confirmed formation of the monomers and composite samples were fabricated respectively by exposing 11 mm diameter discs to blue light. Modulus of the tensile elasticity was tested using a biaxial flexural test and the values were found to be between 1 and 3 GPa in CMA-1, CSMA-2 and their composites. In vitro cell culture, using human Bone Marrow Derived Mesenchymal Stem Cells (BMSCs), confirmed non-toxicity of the samples and finally 3D printing allowed direct extrusion and setting of the bio ink into a mesh-like construct.

Type: Article
Title: Synthesis, Characterisation and 3D Printing of an Isosorbide Based, Light Curable, Degradable Polymer for Potential Application in Maxillofacial Reconstruction
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsbiomaterials.9b00884
Publisher version: https://doi.org/10.1021/acsbiomaterials.9b00884
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Anatomy, Composites, Monomers, 3D printing, Polymers
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10083136
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