Gallarello, A;
Palombi, A;
Annio, G;
Homer-Vanniasinkam, S;
De Momi, E;
Maritati, G;
Torii, R;
... Wurdemann, H; + view all
(2019)
Patient-Specific Aortic Phantom with Tuneable Compliance.
Journal of Engineering and Science in Medical Diagnostics and Therapy
10.1115/1.4044611.
(In press).
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Abstract
Validation of computational models using in vitro phantoms is a non-trivial task, especially in the replication of the mechanical properties of the vessel walls which varies with age and pathophysiological state. In this paper, we present a novel aortic phantom reconstructed from patient-specific data with variable wall compliance that can be tuned without recreating the phantom. The 3D geometry of an aortic arch was retrieved from a Computed Tomography Angiography scan. A rubber-like silicone phantom was manufactured and connected to a compliance chamber in order to tune its compliance. A lumped resistance was also coupled with the system. The compliance of the aortic arch model was validated using the Young's modulus and characterised further with respect to clinically relevant indicators. The silicone model demonstrates that compliance can be finely tuned with this system under pulsatile flow conditions. The phantom replicated values of compliance in the physiological range. Both, the pressure curves and the asymmetrical behaviour of the expansion, are in agreement with the literature. This novel design approach allows obtaining for the first time a phantom with tuneable compliance. Vascular phantoms designed and developed with the methodology proposed in this paper have high potential to be used in diverse conditions. Applications include training of physicians, pre-operative trials for complex interventions, testing of medical devices for cardiovascular diseases and comparative MRI-based computational studies.
| Type: | Article |
|---|---|
| Title: | Patient-Specific Aortic Phantom with Tuneable Compliance |
| DOI: | 10.1115/1.4044611 |
| Publisher version: | https://doi.org/10.1115/1.4044611 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10083026 |
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