Pallett, LJ;
Schmidt, N;
Schurich, A;
(2019)
T cell metabolism in chronic viral infection.
Clinical & Experimental Immunology
, 197
(2)
pp. 143-152.
10.1111/cei.13308.
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Abstract
Summary T cells are a fundamental component of the adaptive immune response in the context of both acute and chronic viral infection. Tight control over the metabolic processes within T cells provides an additional level of immune regulation that is interlinked with nutrient sensing and the continued balancing of co‐stimulatory and co‐inhibitory signals. Underpinning T cell responsiveness for viral control are a number of phenotypic and functional adaptations ensuring adequate nutrient uptake and their utilization. T cells responding to persistent viral infections often exhibit a profile associated with immune cell exhaustion and a dysregulated metabolic profile, driven by a combination of chronic antigenic stimulation and signals from the local microenvironment. Understanding alterations in these metabolic processes provides an important basis for immunotherapeutic strategies to treat persistent infections.
| Type: | Article |
|---|---|
| Title: | T cell metabolism in chronic viral infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/cei.13308 |
| Publisher version: | https://doi.org/10.1111/cei.13308 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, immunometabolism, metabolic exhaustion, T cell, tissue residency, viral infection, immunotherapy, AMINO-ACIDS, GLUTAMINE UPTAKE, ACETYL-COENZYME, MEMORY, TRANSPORTER, ACTIVATION, INHIBITION, REGULATOR, RESPONSES, RECEPTOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081958 |
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