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T cell metabolism in chronic viral infection

Pallett, LJ; Schmidt, N; Schurich, A; (2019) T cell metabolism in chronic viral infection. Clinical & Experimental Immunology , 197 (2) pp. 143-152. 10.1111/cei.13308. Green open access

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Abstract

Summary T cells are a fundamental component of the adaptive immune response in the context of both acute and chronic viral infection. Tight control over the metabolic processes within T cells provides an additional level of immune regulation that is interlinked with nutrient sensing and the continued balancing of co‐stimulatory and co‐inhibitory signals. Underpinning T cell responsiveness for viral control are a number of phenotypic and functional adaptations ensuring adequate nutrient uptake and their utilization. T cells responding to persistent viral infections often exhibit a profile associated with immune cell exhaustion and a dysregulated metabolic profile, driven by a combination of chronic antigenic stimulation and signals from the local microenvironment. Understanding alterations in these metabolic processes provides an important basis for immunotherapeutic strategies to treat persistent infections.

Type: Article
Title: T cell metabolism in chronic viral infection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/cei.13308
Publisher version: https://doi.org/10.1111/cei.13308
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Immunology, immunometabolism, metabolic exhaustion, T cell, tissue residency, viral infection, immunotherapy, AMINO-ACIDS, GLUTAMINE UPTAKE, ACETYL-COENZYME, MEMORY, TRANSPORTER, ACTIVATION, INHIBITION, REGULATOR, RESPONSES, RECEPTOR
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10081958
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