Heinzel, S;
Roeben, B;
Ben-Shlomo, Y;
Lerche, S;
Alves, G;
Barone, P;
Behnke, S;
... Berg, D; + view all
(2016)
Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.
[Review].
Frontiers in Aging Neuroscience
, 8
, Article 147. 10.3389/fnagi.2016.00147.
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Abstract
A growing body of evidence supports a prodromal neurodegenerative process preceding the clinical onset of Parkinson’s disease (PD). Studies have identified several different prodromal markers that may have the potential to predict the conversion from healthy to clinical PD but use considerably different approaches. We systematically reviewed 35 longitudinal studies reporting prodromal PD features and evaluated the methodological quality across 10 different predefined domains. We found limitations in the following domains: PD diagnosis (57% of studies), prodromal marker assessments (51%), temporal information on prodromal markers or PD diagnosis (34%), generalizability of results (17%), statistical methods (accounting for at least age as confounder; 17%), study design (14%), and sample size (9%). However, no limitations regarding drop-out (or bias investigation), or report of inclusion/exclusion criteria or prodromal marker associations were revealed. Lessons learned from these limitations and additional aspects of current prodromal marker studies in PD are discussed to provide a basis for the evaluation of findings and the improvement of future research in prodromal PD. The observed heterogeneity of studies, limitations and analyses might be addressed in future longitudinal studies using a, yet to be established, modular minimal set of assessments improving comparability of findings and enabling data sharing and combined analyses across studies.
| Type: | Article |
|---|---|
| Title: | Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2016.00147 |
| Publisher version: | https://doi.org/10.3389/fnagi.2016.00147 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Parkinson’s disease, prodromal, cohort, prospective, case-control, clinical, longitudinal, marker |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081358 |
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