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Perivascular Spaces in the Brain: Anatomy, Physiology, and Contributions to Pathology of Brain Diseases

Wardlow, J; Benveniste, H; Nedergaard, M; Zlokovic, B; Mestre, H; Lee, H; Doubal, F; ... Black, S; + view all (2019) Perivascular Spaces in the Brain: Anatomy, Physiology, and Contributions to Pathology of Brain Diseases. Nature Reviews Neurology (In press).

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Smith_AAM_Appendix 1. FLQ Network Members.pdf - Accepted version
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Smith_AAM_Gissen Fig. 1 BAs.pdf - Accepted version
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Smith_AAM_Gissen Fig. 1 Albumin and AFP.pdf - Accepted version
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Smith_AAM_Gissen Fig. 2 Albumin and AFP.pdf - Accepted version
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Smith_AAM_Gissen Fig. 3 Albumin and AFP.pdf - Accepted version
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Smith_AAM_Gissen Fig. 5 Albumin and AFP.pdf - Accepted version
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Smith_AAM_Glossary PVS paper NRN.pdf - Accepted version
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Abstract

Perivascular spaces (PVS) represent a range of passageways around arterioles, capillaries and venules in the brain along which a range of substances can move. Roles for PVS in interstitial fluid drainage and immunological protection have been known for decades. However, PVS have come to prominence recently through potential roles in brain interstitial fluid and waste clearance particularly during sleep, and in the pathogenesis of small vessel disease, Alzheimer’s disease and other neurodegenerative and inflammatory disorders. Recent advances have enabled in vivo studies of PVS function in intact rodent models while awake or asleep, of human PVS morphology related to cognition, vascular risk factors, vascular and neurodegenerative brain lesions, sleep patterns and with detailed cerebral haemodynamics. Although research on the PVS is longstanding, many questions remain. What is clear is that normal PVS function is important for maintaining brain health. Notions that PVS are ‘curiosities’ on neuroimaging, or artefacts on pathology, may have delayed scientific progress. Several tools are now available to advance understanding and clinical awareness of PVS in the context of vascular, inflammatory and neurodegenerative diseases. Knowledge of PVS is relevant to clinicians in neurology, psychiatry, geriatric and general medicine, vascular specialists, and radiologists. Here, we review PVS anatomy, physiology and pathology, translating from models to humans, highlighting knowns, unknowns, controversies, and clinical relevance.

Type: Article
Title: Perivascular Spaces in the Brain: Anatomy, Physiology, and Contributions to Pathology of Brain Diseases
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10081129
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