Zhu, J;
Haynes, CJE;
Kieffer, M;
Greenfield, JL;
Greenhalgh, RD;
Nitschke, JR;
Keyser, UF;
(2019)
FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases.
Journal of The American Chemical Society
, 141
(29)
pp. 11358-11362.
10.1021/jacs.9b03566.
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Abstract
A water-soluble self-assembled supramolecular FeII4L4 tetrahedron binds to single stranded DNA, mismatched DNA base pairs, and three-way DNA junctions. Binding of the coordination cage quenches fluorescent labels on the DNA strand, which provides an optical means to detect the interaction and allows the position of the binding site to be gauged with respect to the fluorescent label. Utilizing the quenching and binding properties of the coordination cage, we developed a simple and rapid detection method based on fluorescence quenching to detect unpaired bases in double-stranded DNA.
| Type: | Article |
|---|---|
| Title: | FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/jacs.9b03566 |
| Publisher version: | https://doi.org/10.1021/jacs.9b03566 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081116 |
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