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Instrument-based Tests for Measuring Anterior Chamber Cells in Uveitis: A Systematic Review

Liu, X; Solebo, AL; Faes, L; Beese, S; Braithwaite, T; Round, ME; Panthagani, J; ... Denniston, AK; + view all (2019) Instrument-based Tests for Measuring Anterior Chamber Cells in Uveitis: A Systematic Review. [Review]. Ocular Immunology and Inflammation 10.1080/09273948.2019.1640883. (In press). Green open access

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Abstract

Purpose: New instrument-based techniques for anterior chamber (AC) cell counting can offer automation and objectivity above clinician assessment. This review aims to identify such instruments and its correlation with clinician estimates. Methods: Using standard systematic review methodology, we identified and tabulated the outcomes of studies reporting reliability and correlation between instrument-based measurements and clinician AC cell grading. Results: From 3470 studies, 6 reported correlation between an instrument-based AC cell count to clinician grading. The two instruments were optical coherence tomography (OCT) and laser flare-cell photometry (LFCP). Correlation between clinician grading and LFCP was 0.66–0.87 and 0.06–0.97 between clinician grading and OCT. OCT volume scans demonstrated correlation between 0.75 and 0.78. Line scans in the middle AC demonstrated higher correlation (0.73–0.97) than in the inferior AC (0.06–0.56). Conclusion: AC cell count by OCT and LFP can achieve high levels of correlation with clinician grading, whilst offering additional advantages of speed, automation, and objectivity.

Type: Article
Title: Instrument-based Tests for Measuring Anterior Chamber Cells in Uveitis: A Systematic Review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/09273948.2019.1640883
Publisher version: https://doi.org/10.1080/09273948.2019.1640883
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Anterior chamber cells, aqueous humor, aqueous humour, diagnostic test, laser flare-cell photometry, optical coherence tomography, systematic review, uveitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10080577
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