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Sequential Electro-Anatomical Mapping Methodology and Preliminary Results for Reentry Vulnerability Index Estimation

Orini, M; Hanson, B; Taggart, P; Campos, F; Rinaldi, A; Gill, J; Bishop, M; (2018) Sequential Electro-Anatomical Mapping Methodology and Preliminary Results for Reentry Vulnerability Index Estimation. In: Computing in Cardiology 2018. IEEE: Maastricht, Netherlands. Green open access

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Abstract

Ventricular tachycardia (VT) recurrence after catheter ablation remains frequent and improved ablation strategies are needed. The re-entry vulnerability index (RVI) is an activation-repolarization marker to localize critical sites for VT initiation. Its use is limited since current electro-anatomical mapping systems (EAMS) cannot provide global measurement of activation and repolarization times within a single beat. We carried out a simulation study to assess a simple method to measure RVI using data collected by sequential EAMS and we investigated the effect of background noise, RT variability (σRT ) and ectopics on RVI estimation. The mean correlation coefficient between single ECG beats and a representative template is used as inclusion/exclusion criterion. Localization of the vulnerable region associated with 5% bottom RVI was accurate (sensitivity80±8%, specificity> 99±1%) for moderate to large repolarization variability (5 ≤ σRT ≤ 20 ms) and moderate level of noise (SNR ≥ 10 dB) but it deteriorated for σRT ≥ 25 ms and SNR ≤ 5 dB. Sensitivity remained high even when RVI estimates were only moderately accurate (cc > 0.67 ± 0.05, MAE < 25 ± 1 ms). The number of ectopic beats did not affect the results. In the in-vivo case analyzed, the sites of low RVI and VT exit was close (5.1 mm)

Type: Proceedings paper
Title: Sequential Electro-Anatomical Mapping Methodology and Preliminary Results for Reentry Vulnerability Index Estimation
Event: Computing in Cardiology 2018
Location: Maastricht, Netherlands
Dates: September 23-26, 2018
ISBN-13: 9781728109589
Open access status: An open access version is available from UCL Discovery
DOI: 10.22489/CinC.2018.286
Publisher version: https://doi.org/10.22489/CinC.2018.286
Language: English
Additional information: This is an open-access publication, in which copyright in each article is held by its authors, who grant permission to copy and redistribute their work with attribution, under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/2.5/
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10079577
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