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A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Handa, JT; Bowes Rickman, C; Dick, AD; Gorin, MB; Miller, JW; Toth, CA; Ueffing, M; ... Farrer, LA; + view all (2019) A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nature Communications , 10 , Article 3347. 10.1038/s41467-019-11262-1. Green open access

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Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.

Type: Article
Title: A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-019-11262-1
Publisher version: https://doi.org/10.1038/s41467-019-11262-1
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creative commons.org/licenses/ by/4.0/.
Keywords: biomarkers, macular degeneration, systems biology, visual system
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10079253
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