Gaetani, L;
Salvadori, N;
Lisetti, V;
Eusebi, P;
Mancini, A;
Gentili, L;
Borrelli, A;
... Di Filippo, M; + view all
(2019)
Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis.
Journal of Neurology
, 266
pp. 2157-2163.
10.1007/s00415-019-09398-7.
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Abstract
BACKGROUND: Cognitive impairment (CI) is a disabling symptom of multiple sclerosis (MS). Axonal damage disrupts neural circuits and may play a role in determining CI, but its detection and monitoring are not routinely performed. Cerebrospinal fluid (CSF) neurofilament light chain (NfL) is a promising marker of axonal damage in MS. // OBJECTIVE: To retrospectively examine the relationship between CSF NfL and CI in MS patients. // METHODS: CSF NfL concentration was measured in 28 consecutive newly diagnosed MS patients who underwent a neuropsychological evaluation with the Brief Repeatable Battery of Neuropsychological tests (BRBN). // RESULTS: CSF NfL was higher in patients with overall CI (947.8 ± 400.7 vs 518.4 ± 424.7 pg/mL, p < 0.01), and with impairment in information processing speed (IPS) (820.8 ± 413.6 vs 513.6 ± 461.4 pg/mL, p < 0.05) and verbal fluency (1292 ± 511 vs 582.8 ± 395.4 pg/mL, p < 0.05), and it positively correlated with the number of impaired BRBN tests (r = 0.48, p = 0.01) and cognitive domains (r = 0.47, p = 0.01). Multivariate analyses taking into account potential confounders confirmed these findings. // CONCLUSION: CSF NfL is higher in MS patients with CI and impaired IPS and verbal fluency. Large myelinated axons injury, causing neural disconnection, may be an important determinant of CI in MS and can be reliably measured through CSF NfL.
| Type: | Article |
|---|---|
| Title: | Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00415-019-09398-7 |
| Publisher version: | https://doi.org/10.1007/s00415-019-09398-7 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cerebrospinal fluid, cognitive impairment, information processing speed, multiple sclerosis, neurofilament light chain, verbal fluency |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10079202 |
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