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Advances in brain imaging in multiple sclerosis

Cortese, R; Collorone, S; Ciccarelli, O; Toosy, AT; (2019) Advances in brain imaging in multiple sclerosis. Therapeutic Advances in Neurological Disorders , 12 pp. 1-15. 10.1177/1756286419859722. Green open access

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Abstract

Brain imaging is increasingly used to support clinicians in diagnosing multiple sclerosis (MS) and monitoring its progression. However, the role of magnetic resonance imaging (MRI) in MS goes far beyond its clinical application. Indeed, advanced imaging techniques have helped to detect different components of MS pathogenesis in vivo, which is now considered a heterogeneous process characterized by widespread damage of the central nervous system, rather than multifocal demyelination of white matter. Recently, MRI biomarkers more sensitive to disease activity than clinical disability outcome measures, have been used to monitor response to anti-inflammatory agents in patients with relapsing-remitting MS. Similarly, MRI markers of neurodegeneration exhibit the potential as primary and secondary outcomes in clinical trials for progressive phenotypes. This review will summarize recent advances in brain neuroimaging in MS from the research setting to clinical applications.

Type: Article
Title: Advances in brain imaging in multiple sclerosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1756286419859722
Publisher version: https://doi.org/10.1177%2F1756286419859722
Language: English
Additional information: © 2019 by SAGE Publications Ltd. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/).
Keywords: brain, diagnosis, magnetic resonance imaging, multiple sclerosis, pathogenesis, progression
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10079123
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