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Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis

Coric, D; Ometto, G; Montesano, G; Keane, PA; Balk, LJ; Uitdehaag, BMJ; Petzold, A; ... Denniston, AK; + view all (2019) Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis. European Journal of Neurology 10.1111/ene.14048. (In press). Green open access

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Abstract

Background Occurrence of intermediate uveitis, which is characterized by the presence of vitreous haze (VH), in patients with multiple sclerosis (MS) may be a sign of coexistent inflammatory central nervous system (CNS) disease activity. Using an automated algorithm to quantify VH on optical coherence tomography (OCT) scans, we aimed to investigate whether VH in MS patients is associated with signs of inflammatory CNS disease activity. Methods VH was quantified on OCT macular volume scans of 290 MS patients and 85 healthy controls (HCs). The relationship between VH and clinical, retinal OCT and MRI parameters of inflammatory disease activity was investigated using generalized estimating equations. Results Mean VH scores did not differ between patients and HCs (p=0.629). Six patients (2.1%) showed values higher than the highest of the controls. VH scores did not differ between the different disease types or between eyes with and without a history of optic neuritis (p=0.132). VH was not associated with inner nuclear layer volume on OCT (p=0.233), cerebral T2 lesion load on MRI (p=0.416) or the development of new relapses (p=0.205). Conclusion In this study OCT‐based automated VH estimation did not detect increased vitreous inflammation in MS patients compared to HCs, and did not find an association with CNS inflammatory burden.

Type: Article
Title: Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ene.14048
Publisher version: https://doi.org/10.1111/ene.14048
Language: English
Additional information: © 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Keywords: multiple sclerosis, uveitis, vitreous haze, optical coherence tomography, neuro-ophthalmology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10078991
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