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Organ Preservation into the 2020s: The Era of Dynamic Intervention

Petrenko, A; Carnevale, M; Somov, A; Osorio, J; Rodriguez, J; Guibert, E; Fuller, B; (2019) Organ Preservation into the 2020s: The Era of Dynamic Intervention. Transfusion Medicine and Hemotherapy , 46 (3) pp. 151-172. 10.1159/000499610. Green open access

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Abstract

Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons.

Type: Article
Title: Organ Preservation into the 2020s: The Era of Dynamic Intervention
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000499610
Publisher version: https://doi.org/10.1159/000499610
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Hematology, Immunology, Organ preservation, Organ preservation solutions, Transplantation, UNIVERSITY-OF-WISCONSIN, HYPOTHERMIC MACHINE PERFUSION, ISCHEMIA-REPERFUSION INJURY, ORTHOTOPIC LIVER-TRANSPLANTATION, TROPHIC FACTOR SUPPLEMENTATION, MESENCHYMAL STEM-CELLS, TERM COLD-STORAGE, ENDOTHELIAL GLYCOCALYX, KIDNEY-PRESERVATION, ISCHEMIA/REPERFUSION INJURY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10078381
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