Buljubasic, N;
Vroegindewey, MM;
Oemrawsingh, RM;
Asselbergs, FW;
Cramer, E;
Liem, A;
van der Harst, P;
... Boersma, E; + view all
(2019)
Temporal Pattern of Growth Differentiation Factor-15 Protein After Acute Coronary Syndrome (From the BIOMArCS Study).
American Journal of Cardiology
, 124
(1)
pp. 84-13.
10.1016/j.amjcard.2019.03.049.
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Text (Article)
Asselbergs GDF-15 BIOMArCS study_AJCrevisedarticle.pdf - Accepted Version Download (451kB) | Preview |
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Asselbergs Table 1 Baseline characteristics.pdf - Accepted Version Download (14kB) | Preview |
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Asselbergs Table 2 Temporal evolution 30 days - 1 year.pdf - Accepted Version Download (146kB) | Preview |
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Asselbergs Table 3 Biological variability.pdf - Accepted Version Download (251kB) | Preview |
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Asselbergs Supplemental Tables 4 - 8.pdf - Accepted Version Download (141kB) | Preview |
Abstract
Growth differentiation factor-15 (GDF-15) has appeared as a promising biomarker with strong predictive abilities in acute coronary syndrome (ACS). However, studies are solely based on single measurements in the acute phase of an ACS event. The way GDF-15 patterns in post-ACS patients behave on the long term is largely unknown. We conducted a nested case-control study within our multicenter, prospective, observational biomarker study (BIOMArCS) of 844 ACS patients. Following an index ACS event, high-frequency blood sampling was performed during 1-year of follow-up. GDF-15 was determined batchwise by electrochemiluminescence immunoassays in 37 cases with a recurrent event during 1-year follow-up, and in 74 event-free controls. Cases and controls had a mean ± standard deviation age of 66.9 ± 11.3 years and 81% were men. From 30 days onwards, patients showed stable levels, which were on average 333 (95% confidence interval 68 to 647) pg/mL higher in cases than controls (1704 vs 1371 pg/mL; p value 0.013). Additionally, in the post 30-day period, GDF-15 showed low within-individual variability in both cases and controls. In conclusion, post-ACS patients experiencing a recurrent event had stable and systematically higher GDF-15 levels during 30-day to 1-year follow-up than their event-free counterparts with otherwise similar clinical characteristics. Thus, postdischarge blood sampling might be used throughout the course of 1 year to improve prognostication, whereas, in view of the low within-individual variation, the number of repeated sampling moments might be limited.
| Type: | Article |
|---|---|
| Title: | Temporal Pattern of Growth Differentiation Factor-15 Protein After Acute Coronary Syndrome (From the BIOMArCS Study) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.amjcard.2019.03.049 |
| Publisher version: | https://doi.org/10.1016/j.amjcard.2019.03.049 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Acute coronary syndrome; Biomarkers; Growth differentiation factor-15; Repeated measurements |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10076170 |
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