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Microwave-Assisted Rapid Synthesis of γ-Cyclodextrin Metal–Organic Frameworks for Size Control and Efficient Drug Loading

Liu, B; He, Y; Han, L; Singh, V; Xu, X; Guo, T; Meng, F; ... Zhang, J; + view all (2017) Microwave-Assisted Rapid Synthesis of γ-Cyclodextrin Metal–Organic Frameworks for Size Control and Efficient Drug Loading. Crystal Growth & Design , 17 (4) pp. 1654-1660. 10.1021/acs.cgd.6b01658. Green open access

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Abstract

The micron and nanometer-sized γ-cyclodextrin metal–organic frameworks (γ-CD-MOFs) were successfully synthesized using the microwave technique for the first time for rapid and facile synthesis. Polyethylene glycol 20000 (PEG 20000) was used as surfactant to control the size and morphology of γ-CD-MOFs. The as-synthesized γ-CD-MOFs were characterized using various techniques, including X-ray powder diffraction (PXRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and N2 adsorption. The increment in the reaction time and MeOH ratio dramatically damaged the crystalline integrity of γ-CD-MOFs. Fenbufen was selected as a model drug to evaluate the loading characteristics of γ-CD-MOF crystals. As a result, the nanometer sized γ-CD-MOFs (100–300 nm) showed rapid and higher adsorption (196 mg g–1) of Fenbufen in EtOH when compared with the micron crystals. The adsorption parameters fitted well to a pseudo-second-order kinetic model and chemisorption of Fenbufen was further supported by molecular docking illustrations. In summary, the controlled synthesis of γ-CD-MOFs was successfully achieved by microwave assisted method and resultant crystals were further evaluated for potential drug delivery applications.

Type: Article
Title: Microwave-Assisted Rapid Synthesis of γ-Cyclodextrin Metal–Organic Frameworks for Size Control and Efficient Drug Loading
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.cgd.6b01658
Publisher version: https://doi.org/10.1021/acs.cgd.6b01658
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10075856
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