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Cellular imaging of inherited retinal diseases using adaptive optics

Gill, JS; Moosajee, M; Dubis, AM; (2019) Cellular imaging of inherited retinal diseases using adaptive optics. Eye , 33 pp. 1683-1698. 10.1038/s41433-019-0474-3. Green open access

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Abstract

Adaptive optics (AO) is an insightful tool that has been increasingly applied to existing imaging systems for viewing the retina at a cellular level. By correcting for individual optical aberrations, AO offers an improvement in transverse resolution from 10-15 μm to ~2 μm, enabling assessment of individual retinal cell types. One of the settings in which its utility has been recognised is that of the inherited retinal diseases (IRDs), the genetic and clinical heterogeneity of which warrants better cellular characterisation. In this review, we provide a summary of the basic principles of AO, its integration into multiple retinal imaging modalities and its clinical applications, focusing primarily on IRDs. Furthermore, we present a comprehensive summary of AO-based cellular findings in IRDs according to their associated disease-causing genes.

Type: Article
Title: Cellular imaging of inherited retinal diseases using adaptive optics
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41433-019-0474-3
Publisher version: https://doi.org/10.1038/s41433-019-0474-3
Language: English
Additional information: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Predictive markers, Prognostic markers
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10075811
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