Constantinescu, R;
Krysl, D;
Bergquist, F;
Andren, K;
Malmestroem, C;
Asztely, F;
Axelsson, M;
... Zetterberg, H; + view all
(2016)
Cerebrospinal fluid markers of neuronal and glial cell damage to monitor disease activity and predict long-term outcome in patients with autoimmune encephalitis.
European Journal of Neurology
, 23
(4)
pp. 796-806.
10.1111/ene.12942.
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Abstract
Background and purpose Clinical symptoms and long‐term outcome of autoimmune encephalitis are variable. Diagnosis requires multiple investigations, and treatment strategies must be individually tailored. Better biomarkers are needed for diagnosis, to monitor disease activity and to predict long‐term outcome. The value of cerebrospinal fluid (CSF) markers of neuronal [neurofilament light chain protein (NFL), and total tau protein (T‐tau)] and glial cell [glial fibrillary acidic protein (GFAP)] damage in patients with autoimmune encephalitis was investigated. Methods Demographic, clinical, magnetic resonance imaging, CSF and antibody‐related data of 25 patients hospitalized for autoimmune encephalitis and followed for 1 year were retrospectively collected. Correlations between these data and consecutive CSF levels of NFL, T‐tau and GFAP were investigated. Disability, assessed by the modified Rankin scale, was used for evaluation of disease activity and long‐term outcome. Results The acute stage of autoimmune encephalitis was accompanied by high CSF levels of NFL and T‐tau, whereas normal or significantly lower levels were observed after clinical improvement 1 year later. NFL and T‐tau reacted in a similar way but at different speeds, with T‐tau reacting faster. CSF levels of GFAP were initially moderately increased but did not change significantly later on. Final outcome (disability at 1 year) directly correlated with CSF‐NFL and CSF‐GFAP levels at all time‐points and with CSF‐T‐tau at 3 ± 1 months. This correlation remained significant after age adjustment for CSF‐NFL and T‐tau but not for GFAP. Conclusion In autoimmune encephalitis, CSF levels of neuronal and glial cell damage markers appear to reflect disease activity and long‐term disability.
| Type: | Article |
|---|---|
| Title: | Cerebrospinal fluid markers of neuronal and glial cell damage to monitor disease activity and predict long-term outcome in patients with autoimmune encephalitis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ene.12942 |
| Publisher version: | https://doi.org/10.1111/ene.12942 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, autoimmune encephalitis, cerebrospinal fluid, GFAP, glial fibrillary acidic protein, neurofilaments, neuronal cell membrane antigens, neuronal damage markers, neuronal surface antigens, NFL, tau proteins, NMDA-RECEPTOR ENCEPHALITIS, CREUTZFELDT-JAKOB-DISEASE, AMYOTROPHIC-LATERAL-SCLEROSIS, FIBRILLARY ACIDIC PROTEIN, NEUROFILAMENT PROTEIN, CSF NEUROFILAMENT, NEURODEGENERATIVE DISEASES, LIMBIC ENCEPHALITIS, ALZHEIMER-DISEASE, TAU-PROTEIN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074817 |
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