Grand, J;
Kjaergaard, J;
Nielsen, N;
Friberg, H;
Cronberg, T;
Bro-Jeppesen, J;
Karsdal, MA;
... Hassager, C; + view all
(2019)
Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest.
Biomarkers
, 24
(6)
pp. 584-591.
10.1080/1354750X.2019.1609580.
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Zetterberg_Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest_AAM.pdf - Published Version Download (1MB) | Preview |
Abstract
Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. / Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 hours after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 hours after OHCA. The primary endpoint was neurological outcome. / Results: Median (quartile 1 – quartile 3) tau-A (ng/ml) values were 58 (43-71) versus 51 (43-67), 72 (57-84) versus 71 (59-82) and 76 (61-92) versus 75 (64-89) for good versus unfavorable outcome at 24, 48, and 72 h, respectively (pgroup = 0.95). Median tau C (ng/ml) values were 38 (29-50) versus 36 (29-49), 49 (38-58) versus 48 (33-59), and 48 (39-59) versus 48 (36-62) (pgroup = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 hours; tau-A: 0.51 and tau-C: 0.51). / Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA.
| Type: | Article |
|---|---|
| Title: | Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/1354750X.2019.1609580 |
| Publisher version: | https://doi.org/10.1080/1354750X.2019.1609580 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Serum biomarkers; tau fragments; neurological outcome; Out-of-Hospital Cardiac Arrest; prognosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10073498 |
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