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Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis

Hayes, JF; Osborn, DPJ; Lundin, A; Dalman, C; (2019) Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis. Journal of Psychopharmacology , 33 (4) pp. 532-534. 10.1177/0269881119827883. Green open access

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Abstract

Background: There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation. Aim: The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure. Methods: We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007–31 December 2016 (n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years). Results: Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1–4 years after treatment cessation. Conclusion: We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.

Type: Article
Title: Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0269881119827883
Publisher version: https://doi.org/10.1177/0269881119827883
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Relapse, hospitalization, first episode psychosis, antipsychotic medication
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10072803
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