UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Crystal Engineering in Continuous Plug-Flow Crystallizers

Besenhard, MO; Neugebauer, P; Scheibelhofer, O; Khinast, JG; (2017) Crystal Engineering in Continuous Plug-Flow Crystallizers. Crystal Growth & Design , 17 (12) pp. 6432-6444. 10.1021/acs.cgd.7b01096. Green open access

[thumbnail of acs.cgd.7b01096.pdf]
Preview
Text
acs.cgd.7b01096.pdf - Published Version

Download (8MB) | Preview

Abstract

Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today’s crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise control of the crystal size and shape distribution, as well as polymorphic composition. Tubular crystallizers utilizing segmented flow such as the one presented in our work can provide plug flow characteristics, fast heating and cooling, allowing for rapid changes of the supersaturation. This makes them superior for crystal engineering over common crystallizers. Characterization of particle transport, however, revealed that careful selection of process parameters, such as tubing diameter, flow rates, solvents, etc., is crucial to achieve the full benefits of such reactors.

Type: Article
Title: Crystal Engineering in Continuous Plug-Flow Crystallizers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.cgd.7b01096
Publisher version: https://doi.org/10.1021/acs.cgd.7b01096
Language: English
Additional information: This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10071571
Downloads since deposit
184Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item