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Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis

Brown, W; Chowdhury, A; Kanber, B; Prados Carrasco, F; Eshaghi, A; Sudre, CH; Pardini, M; ... Chard, DT; + view all (2019) Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis. Multiple Sclerosis Journal (In press). Green open access

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Abstract

Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging - is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might therefore differ in PPMS and SPMS if these follicles are responsible. / Objective: We assessed cortical and periventricular MTR gradients in PPMS; and compared gradients between people with PPMS and SPMS. / Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). / Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p<0.0001) and SPMS (1.360 pu/band, p<0.0001). The cortical gradient was also significantly shallower in healthy controls (-2.860 pu/band) compared to PPMS (-3.214 pu/band, p=0.038) and SPMS (-3.328 pu/band, p=0.016)). / Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS suggesting comparable underlying pathological processes.

Type: Article
Title: Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis
Open access status: An open access version is available from UCL Discovery
Publisher version: https://journals.sagepub.com/home/msj
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Primary progressive multiple sclerosis; secondary progressive multiple sclerosis, magnetisation transfer ratio; normal-appearing white matter
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10071479
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