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Tafamidis for the treatment of transthyretin amyloidosis

Lorenzini, M; Elliott, PM; (2019) Tafamidis for the treatment of transthyretin amyloidosis. Future Cardiology , 15 (2) pp. 53-61. 10.2217/fca-2018-0078. Green open access

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Abstract

Transthyretin (TTR) related cardiomyopathy is an underdiagnosed cause of heart failure but is increasingly recognized in various settings - from patients admitted with heart failure to symptomatic aortic stenosis - and is rapidly becoming the most frequent form of systemic amyloidosis. Following the recent publication of the landmark ATTR-ACT trial that showed tafamidis to be the first treatment to improve survival in patients with TTR-related cardiac amyloidosis and heart failure, we reviewed the drug's rationale, characteristics and evidence supporting its use in TTR amyloidosis.

Type: Article
Title: Tafamidis for the treatment of transthyretin amyloidosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/fca-2018-0078
Publisher version: https://doi.org/10.2217/fca-2018-0078
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: amyloidosis, cardiomyopathy, tafamidis, transthyretin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10069107
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