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Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation

Besson, P; Muthalib, M; Dray, G; Rothwell, J; Perrey, S; (2019) Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation. Brain Research , 1710 pp. 181-187. 10.1016/j.brainres.2019.01.003. Green open access

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Abstract

Functional targeting with anodal high-definition transcranial direct current stimulation (HD-atDCS) of involved brain areas during performance of a motor task (online) may facilitate sensorimotor cortex neuroplasticity compared to performing the motor task after HD-atDCS (offline). The aim of this study was to employ functional near-infrared spectroscopy to compare the time course of motor task-related changes in sensorimotor cortex activation between online and offline HD-atDCS. We hypothesized that online HD-atDCS would have a greater effect on task-related sensorimotor cortex activation than offline HD-atDCS. In a within-subject sham controlled and randomized study design, 9 healthy participants underwent 3 HD-atDCS sessions (online, offline and sham) targeting the left sensorimotor cortex separated by 1 week. Functional near-infrared spectroscopy hemodynamic changes were measured from the left sensorimotor cortex during a simple finger opposition motor task before (Pre), immediately (T1) and 30 min after (T2) each session. The movement rates were not different between (online, offline, sham) or within (Pre, T1, T2) sessions. At T2, online HD-atDCS was associated with a significant increase (large effect size) in sensorimotor cortex activation (Hedges g = 1.01, p<0.001) when compared to sham; there was a nonsignificant trend to increase activation between offline and sham (Hedges g = 0.52, p=0.05) and between online and offline (Hedges g = 0.53, p=0.06). Concurrent application of HD-atDCS during a motor task may produce larger sensorimotor cortex activation than sequential application.

Type: Article
Title: Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.brainres.2019.01.003
Publisher version: https://doi.org/10.1016/j.brainres.2019.01.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: functional neuroimaging, high-definition montage, neuromodulation, neurovascular coupling, online, plasticity
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10067141
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