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Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

Uijl, A; Koudstaal, S; Direk, K; Denaxas, S; Groenwold, RHH; Banerjee, A; Hoes, AW; ... Asselbergs, FW; + view all (2019) Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records. European Journal of Heart Failure 10.1002/ejhf.1350. (In press). Green open access

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Abstract

AIMS: Several risk factors for incident heart failure (HF) have been previously identified, however large electronic health records (EHR) datasets may provide the opportunity to examine the consistency of risk factors across different subgroups from the general population. METHODS AND RESULTS: We used linked EHR data from 2000 to 2010 as part of the UK-based CALIBER resource to select a cohort of 871 687 individuals 55 years or older and free of HF at baseline. The primary endpoint was the first record of HF from primary or secondary care. Cox proportional hazards analysis was used to estimate hazard ratios for associations between risk factors and incident HF, separately for men and women and by age category: 55-64, 65-74, and > 75 years. During 5.8 years of median follow-up, a total of 47 987 incident HF cases were recorded. Age, social deprivation, smoking, sedentary lifestyle, diabetes, atrial fibrillation, chronic obstructive pulmonary disease, body mass index, haemoglobin, total white blood cell count and creatinine were associated with HF. Smoking, atrial fibrillation and diabetes showed stronger associations with incident HF in women compared to men. CONCLUSION: We confirmed associations of several risk factors with HF in this large population-based cohort across age and sex subgroups. Mainly modifiable risk factors and comorbidities are strongly associated with incident HF, highlighting the importance of preventive strategies targeting such risk factors for HF.

Type: Article
Title: Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ejhf.1350
Publisher version: https://doi.org/10.1002/ejhf.1350
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Electronic health records, Heart failure, Incidence, Population attributable risk, Risk factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: https://discovery.ucl.ac.uk/id/eprint/10065758
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