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Promising strategies to minimize reperfusion injury in STEMI

Bulluck, H; Yellon, RL; Yellon, DM; (2016) Promising strategies to minimize reperfusion injury in STEMI. Minerva Cardioangiologica , 64 (3) pp. 284-294. Green open access

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Abstract

Morbidity in patients presenting with acute ST-segment elevation myocardial infarction remains significant despite prompt reperfusion by primary percutaneous coronary intervention. This has been partly attributed to "myocardial reperfusion injury" whereby the process of restoring coronary blood flow paradoxically induces myocardial injury and cardiomyocyte death, mitigating the full beneficial effects of reperfusion. A large number of cardioprotective therapies to reduce myocardial infarct size have been investigated in preclinical and small proof-of-concept clinical studies with mixed results. In this article, we provide an overview of the most promising cardioprotective therapies for reducing myocardial infarct size that warrant further investigation in outcome studies.

Type: Article
Title: Promising strategies to minimize reperfusion injury in STEMI
Open access status: An open access version is available from UCL Discovery
Publisher version: https://www.minervamedica.it/en/journals/minerva-c...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10065585
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