Curtis, D;
Emmett, W;
(2017)
Association study of schizophrenia with variants in miR-137 binding sites.
bioRxiv
Preview |
Text
Curtis_SZmiR137.081117.pdf - Accepted Version Download (307kB) | Preview |
Abstract
There is strong cumulative evidence for the involvement of miR-137 and its targets in the aetiology of schizophrenia. Here we test whether variants, especially rare variants, in miR-137 binding sites are associated with schizophrenia in an exome-sequenced sample of 4225 cases and 5834 controls. A weighted burden test using 372 variants was significant at p=0.024. The sample size is too small to implicate individual variants or genes but overall this finding provides further support for the hypothesis that disruption of miR-137 binding sites can increase the risk of schizophrenia, perhaps by leading to over-expression of the target gene. These findings could be followed up by genotyping these variants in larger samples and by experimentally testing whether they do indeed effect expression. When carrying out exome sequencing it is important to include UTRs so that disruption of microRNA bindings sites can be detected.
Type: | Working / discussion paper |
---|---|
Title: | Association study of schizophrenia with variants in miR-137 binding sites |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1101/150409 |
Publisher version: | https://doi.org/10.1101/150409 |
Language: | English |
Additional information: | This is a pre-print version. For information on re-use, please refer to BioRxiv's terms and conditions. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
URI: | https://discovery.ucl.ac.uk/id/eprint/10064659 |
Archive Staff Only
View Item |