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CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Düzel, E; Berron, D; Schütze, H; Cardenas-Blanco, A; Metzger, C; Betts, M; Ziegler, G; ... Jessen, F; + view all (2018) CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring , 10 pp. 782-790. 10.1016/j.dadm.2018.10.003. Green open access

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Abstract

We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images. Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses. Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

Type: Article
Title: CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dadm.2018.10.003
Publisher version: https://doi.org/10.1016/j.dadm.2018.10.003
Language: English
Additional information: Copyright © 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
Keywords: Alzheimer's disease (AD), Subjective cognitive decline (SCD), Mild cognitive impairment (MCI), Longitudinal, Cerebrospinal fluid (CSF), Aβ42, TauApolipoprotein E (APOE), Magnetic resonance imaging (MRI), Positron emission tomography (PET)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10064598
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