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A method for determining local pulse wave velocity in human ascending aorta from sequential ultrasound measurements of diameter and velocity

Negoita, M; Hughes, AD; Parker, KH; Khir, AW; (2018) A method for determining local pulse wave velocity in human ascending aorta from sequential ultrasound measurements of diameter and velocity. Physiological Measurement , 39 (11) , Article 114009. 10.1088/1361-6579/aae8a0. Green open access

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Abstract

Background: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and predicts cardiovascular events independently of blood pressure. Currently, PWV is commonly measured by the foot-to-foot technique thus giving a global estimate of large arterial stiffness. However, and despite its importance, methods to measure the stiffness of the ascending aorta are limited. Objective: To introduce a method for calculating local PWV in the human ascending aorta using non-invasive ultrasound measurements of its diameter (D) and flow velocity (U). Approach: Ten participants (four females) were recruited from Brunel University students. Ascending aortic diameter and velocity were recorded with a GE Vivid E95 equipped with a 1.5–4.5 MHz phased array transducer using M-mode in the parasternal long axis view and pulse wave Doppler in the apical five chamber view respectively. Groups of six consecutive heartbeats were selected from each 20 s run based on the most similar cycle length resulting in three groups for D and three for U each with six waveforms. Each D waveform was paired with each U waveform to calculate PWV using ln(D)U-loop method. Main results: The diastolic portions of the diameters or velocities waveforms were truncated to allow the pairs to have equal length and were used to construct ln(D)U-loops. The trimmed average, excluding 10% of extreme values, resulting from the 324 loops was considered representative for each participant. Overall mean local PWV for all participants was 4.1(SD  =  0.9) m s−1. Significance: Local PWV can be measured non-invasively in the ascending aorta using ultrasound measurements of diameter and flow velocity This should facilitate more widespread assessment of ascending aortic stiffness in larger studies.

Type: Article
Title: A method for determining local pulse wave velocity in human ascending aorta from sequential ultrasound measurements of diameter and velocity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1361-6579/aae8a0
Publisher version: https://doi.org/10.1088/1361-6579/aae8a0
Language: English
Additional information: Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Keywords: ultrasound imaging, arterial stiffness, pulse wave velocity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10064559
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