Huang, W-Y;
Davies, G-L;
Davis, JJ;
(2013)
Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death.
Chemistry - A European Journal
, 19
(52)
pp. 17891-17898.
10.1002/chem.201303239.
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Abstract
A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable efficacy on conjugating a specific caspase‐cascade‐activating cytochrome to such cytosol‐accessing particles.
| Type: | Article |
|---|---|
| Title: | Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/chem.201303239 |
| Publisher version: | https://doi.org/10.1002/chem.201303239 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, apoptosis, endosomal escape, nanomaterials, proteins, therapeutics, DRUG-DELIVERY, INTRACELLULAR DELIVERY, CONTROLLED-RELEASE, PROTEIN, PH, ENDOCYTOSIS, LYSOSOMES, APOPTOSIS, FUSION, CYTOTOXICITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10063837 |
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