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Heparin-stabilised iron oxide for MR applications: a relaxometric study

Ternent, L; Mayoh, DA; Lees, MR; Davies, G-L; (2016) Heparin-stabilised iron oxide for MR applications: a relaxometric study. Journal of Materials Chemistry B , 4 (18) pp. 3065-3074. 10.1039/c6tb00832a. Green open access

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Abstract

Superparamagnetic nanoparticles have strong potential in biomedicine and have seen application as clinical magnetic resonance imaging (MRI) contrast agents, though their popularity has plummeted in recent years, due to low efficacy and safety concerns, including haemagglutination. Using an in situ procedure, we have prepared colloids of magnetite nanoparticles, exploiting the clinically approved anti-coagulant, heparin, as a templating stabiliser. These colloids, stable over several days, produce exceptionally strong MRI contrast capabilities particularly at low fields, as demonstrated by relaxometric investigations using nuclear magnetic resonance dispersion (NMRD) techniques and single field r1 and r2 relaxation measurements. This behaviour is due to interparticle interactions, enhanced by the templating effect of heparin, resulting in strong magnetic anisotropic behaviour which closely maps particle size. The nanocomposites have also reliably prevented protein-adsorption triggered thrombosis typical of non-stabilised nanoparticles, showing great potential for in vivo MRI diagnostics.

Type: Article
Title: Heparin-stabilised iron oxide for MR applications: a relaxometric study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c6tb00832a
Publisher version: https://doi.org/10.1039/c6tb00832a
Language: English
Additional information: Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10061850
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