Rowley, CD;
Tabrizi, SJ;
Scahill, R;
Leavitt, BR;
Roos, RAC;
Durr, A;
Bock, NA;
(2018)
Altered Intracortical T1-Weighted/T2-Weighted Ratio Signal in Huntington’s Disease.
Frontiers in Neuroscience
, 12
, Article 805. 10.3389/fnins.2018.00805.
Preview |
Text
Tabrizi_Rowley CD et al Front Neurosci Nov 2018.pdf - Published Version Download (11MB) | Preview |
Abstract
Huntington’s disease (HD) is a genetic neurodegenerative disorder that is characterized by neuronal cell death. Although medium spiny neurons in the striatum are predominantly affected, other brain regions including the cerebral cortex also degenerate. Previous structural imaging studies have reported decreases in cortical thickness in HD. Here we aimed to further investigate changes in cortical tissue composition in vivo in HD using standard clinical T1-weighted (T1W) and T2-weighted (T2W) magnetic resonance images (MRIs). 326 subjects from the TRACK-HD dataset representing healthy controls and four stages of HD progression were analyzed. The intracortical T1W/T2W intensity was sampled in the middle depth of the cortex over 82 regions across the cortex. While these previously collected images were not optimized for intracortical analysis, we found a significant increase in T1W/T2W intensity (p < 0.05 Bonferroni-Holm corrected) beginning with HD diagnosis. Increases in ratio intensity were found in the insula, which then spread to ventrolateral frontal cortex, superior temporal gyrus, medial temporal gyral pole, and cuneus with progression into the most advanced HD group studied. Mirroring past histological reports, this increase in the ratio image intensity may reflect disease-related increases in myelin and/or iron in the cortex. These findings suggest that future imaging studies are warranted with imaging optimized to more sensitively and specifically assess which features of cortical tissue composition are abnormal in HD to better characterize disease progression.
| Type: | Article |
|---|---|
| Title: | Altered Intracortical T1-Weighted/T2-Weighted Ratio Signal in Huntington’s Disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnins.2018.00805 |
| Publisher version: | https://doi.org/10.3389/fnins.2018.00805 |
| Language: | English |
| Additional information: | Copyright © 2018 Rowley, Tabrizi, Scahill, Leavitt, Roos, Durr and Bock. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Huntington’s disease, MRI, cerebral cortex, myelin, neurodegeneration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10061801 |
Archive Staff Only
 |
View Item |
