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Molecular bionics – engineering biomaterials at the molecular level using biological principles

Rodriguez Arco, L; Poma, A; Ruiz-Perez, L; Scarpa, E; Ngamkham, K; Battaglia, G; (2019) Molecular bionics – engineering biomaterials at the molecular level using biological principles. Biomaterials , 192 pp. 26-50. 10.1016/j.biomaterials.2018.10.044. Green open access

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Abstract

Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.

Type: Article
Title: Molecular bionics – engineering biomaterials at the molecular level using biological principles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biomaterials.2018.10.044
Publisher version: http://doi.org/10.1016/j.biomaterials.2018.10.044
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: molecular bionics, biomaterials, supramolecular chemistry, organic chemistry, topology, biomedicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10061106
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