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Effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network

Zhang, L; Fan, D; Wang, Q; Baier, G; (2018) Effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network. Chaos , 28 (10) , Article 106322. 10.1063/1.5036690. Green open access

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Abstract

Brain-derived neurotrophic factor (BDNF) has recently been implicated in the modulation of receptor activation leading to dynamic state transitions in temporal lobe epilepsy (TLE). In addition, the crucial role of neuronal noise in these transitions has been studied in electrophysiological experiments. However, the precise role of these factors during seizure generation in TLE is not known. Building on a previously proposed model of an epileptogenic hippocampal network, we included the actions of BDNF-regulated receptors and intrinsic noise. We found that the effects of both BDNF and noise can increase the activation of N-methyl-D-aspartate receptors leading to excessive C a 2 + flux, which induces abnormal fast spiking and bursting. Our results indicate that the combined effects have a strong influence on the seizure-generating network, resulting in higher firing frequency and amplitude. As correlations between firing increase, the synchronization of the entire network increases, a marker of the ictogenic transitions from normal to seizures-like dynamics. Our work on the effects of BDNF dynamics in a noisy environment might lead to an improved model-based understanding of the pathological mechanisms in TLE.

Type: Article
Title: Effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1063/1.5036690
Publisher version: https://doi.org/10.1063/1.5036690
Language: English
Additional information: This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10061001
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