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Penalised maximum likelihood estimation for multi-state models

Mariano Machado, Robson José; (2018) Penalised maximum likelihood estimation for multi-state models. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Multi-state models can be used to analyse processes where change of status over time is of interest. In medical research, processes are commonly defined by a set of living states and a dead state. Transition times between living states are often interval censored. In this case, models are usually formulated in a Markov processes framework. The likelihood function is then constructed using transition probabilities. Models are specified using proportional hazards for the effect of covariates on transition intensities. Time-dependency is usually defined by parametric models, which can represent a strong model assumption. Semiparametric hazards specification with splines is a more flexible method for modelling time-dependency in multi-state models. Penalised maximum likelihood is used to estimate these models. Selecting the optimal amount of smoothing is challenging as the problem involves multiple penalties. This thesis aims to develop methods to estimate multi-state models with splines for interval-censored data. We propose a penalised likelihood method to estimate multi-state models that allow for parametric and semiparametric hazards specifications. The estimation is based on a scoring algorithm, and a grid search method to estimate the smoothing parameters. This method is shown using an application to ageing research. Furthermore, we extend the proposed method by developing a computationally more efficient method to estimate multi-state models with splines. For this extension, the estimation is based on a scoring algorithm, and an automatic smoothing parameters selection. The extended method is illustrated with two data analyses and a simulation study.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Penalised maximum likelihood estimation for multi-state models
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2018. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10060352
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