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Global Expansion of Mycobacterium Tuberculosis Lineage 4 Shaped by Colonial Migration and Local Adaptation

Brynildsrud, OB; Pepperell, CS; Suffys, P; Grandjean, L; Monteserin, J; Debech, N; Bohlin, J; ... Eldholm, V; + view all (2018) Global Expansion of Mycobacterium Tuberculosis Lineage 4 Shaped by Colonial Migration and Local Adaptation. Science Advances , 4 (10) , Article eaat5869. 10.1126/sciadv.aat5869. Green open access

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Abstract

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

Type: Article
Title: Global Expansion of Mycobacterium Tuberculosis Lineage 4 Shaped by Colonial Migration and Local Adaptation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.aat5869
Publisher version: https://doi.org/10.1126/sciadv.aat5869
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license(http://creativecommons.org/licenses/by/4.0/), which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10059909
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