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Evaluating combinations of diagnostic tests to discriminate different dementia types

Bruun, M; Rhodius-Meester, HFM; Koikkalainen, J; Baroni, M; Gjerum, L; Lemstra, AW; Barkhof, F; ... van der Flier, WM; + view all (2018) Evaluating combinations of diagnostic tests to discriminate different dementia types. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 10 pp. 509-518. 10.1016/j.dadm.2018.07.003. Green open access

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Abstract

INTRODUCTION: We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia. METHODS: In this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal dementia, 61 dementia with Lewy bodies, 38 vascular dementia, and 302 controls. We used a classifier to assess accuracy for individual performance and combinations of cognitive tests, cerebrospinal fluid biomarkers, and automated magnetic resonance imaging features for pairwise differentiation between dementia types. RESULTS: Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78% to 97%. DISCUSSION: Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.

Type: Article
Title: Evaluating combinations of diagnostic tests to discriminate different dementia types
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dadm.2018.07.003
Publisher version: http://dx.doi.org/10.1016/j.dadm.2018.07.003
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Alzheimer's disease, Biomarkers, CSF, Clinical decision support system, Dementia with Lewy bodies, Diagnostic test assessment, Differential diagnosis, Frontotemporal dementia, MRI, Vascular dementia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10059599
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