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Major Depression Impairs the Use of Reward Values for Decision-Making

Rupprechter, S; Stankevicius, A; Huys, QJM; Steele, JD; Seriès, P; (2018) Major Depression Impairs the Use of Reward Values for Decision-Making. Scientific Reports , 8 (1) , Article 13798. 10.1038/s41598-018-31730-w. Green open access

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Abstract

Depression is a debilitating condition with a high prevalence. Depressed patients have been shown to be diminished in their ability to integrate their reinforcement history to adjust future behaviour during instrumental reward learning tasks. Here, we tested whether such impairments could also be observed in a Pavlovian conditioning task. We recruited and analysed 32 subjects, 15 with depression and 17 healthy controls, to study behavioural group differences in learning and decision-making. Participants had to estimate the probability of some fractal stimuli to be associated with a binary reward, based on a few passive observations. They then had to make a choice between one of the observed fractals and another target for which the reward probability was explicitly given. Computational modelling was used to succinctly describe participants’ behaviour. Patients performed worse than controls at the task. Computational modelling revealed that this was caused by behavioural impairments during both learning and decision phases. Depressed subjects showed lower memory of observed rewards and had an impaired ability to use internal value estimations to guide decision-making in our task.

Type: Article
Title: Major Depression Impairs the Use of Reward Values for Decision-Making
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-018-31730-w
Publisher version: https://doi.org/10.1038/s41598-018-31730-w
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10058748
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