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Potential of Continuous Manufacturing for Liposomal Drug Products

Worsham, RD; Thomas, V; Farid, SS; (2018) Potential of Continuous Manufacturing for Liposomal Drug Products. Biotechnology Journal , Article e1700740. 10.1002/biot.201700740. Green open access

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Abstract

Over the last several years, continuous manufacturing of pharmaceuticals has evolved from bulk APIs and solid oral dosages into the more complex realm of biologics. The development of continuous downstream processing techniques has allowed biologics manufacturing to realize the benefits (e.g., improved economics, more consistent quality) that come with continuous processing. If relevant processing techniques and principles are selected, the opportunity arises to develop continuous manufacturing designs for additional pharmaceutical products including liposomal drug formulations. Liposome manufacturing has some inherent aspects that make it favorable for a continuous process. Other aspects such as formulation refinement, materials of construction, and aseptic processing need development, but present an achievable challenge. This paper reviews the current state of continuous manufacturing technology applicable to liposomal drug product manufacturing and an assessment of the challenges and potential of this application.

Type: Article
Title: Potential of Continuous Manufacturing for Liposomal Drug Products
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/biot.201700740
Publisher version: https://doi.org/10.1002/biot.201700740
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Aseptic processing, continuous manufacturing, liposomes, single-use, tangential flow filtration (TFF)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10055841
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