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Predicting treatment response in depression: the role of anterior cingulate cortex

Godlewska, BR; Browning, M; Norbury, R; Igoumenou, A; Cowen, PJ; Harmer, CJ; (2018) Predicting treatment response in depression: the role of anterior cingulate cortex. International Journal of Neuropsychopharmacology , 21 (11) pp. 988-996. 10.1093/ijnp/pyy069. Green open access

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Abstract

Background: Identification of biomarkers predicting therapeutic outcome of antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right treatment for a given individual with depression. In the current study, we explored the potential of pretreatment pregenual anterior cingulate cortex activity as a putative biomarker of treatment response. // Methods: Thirty-two medication-free patients with depression were treated for 6 weeks with a selective serotonin reuptake inhibitor, escitalopram. Before treatment began, patients underwent an fMRI scan testing response to brief, masked, presentations of facial expression depicting sadness and happiness. // Results: After 6 weeks of treatment, there were 20 selective serotonin reuptake inhibitor responders and 12 nonresponders. Increased pretreatment pregenual anterior cingulate cortex activity to sad vs happy faces was observed in responders relative to nonresponders. A leave-one-out analysis suggested that activity in the anterior cingulate cortex was able to predict response status at the level of the individual participant. // Conclusions: The study supports the notion of pregenual anterior cingulate cortex as a promising predictor of antidepressant response.

Type: Article
Title: Predicting treatment response in depression: the role of anterior cingulate cortex
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ijnp/pyy069
Publisher version: https://doi.org/10.1093/ijnp/pyy069
Language: English
Additional information: © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: anterior cingulate cortex, depression, selective serotonin reuptake inhibitors, treatment response prediction, functional magnetic resonance imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10055588
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