Bell, Gavin S.; (2018) Developments of iron oxide nanoparticles for magnetic thermotherapy and multimodal imaging. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

Current methods of cancer therapy and detection still warrant high demand and great developments. Utilising the fundamental magnetism of iron oxide nanoparticles, it is possible to harness that magnetic power for the development of new, influential therapeutic and imaging modalities. In this thesis, a detailed look into the use of iron oxide nanoparticles as a material for magnetic thermotherapy and bio-imaging will be undertaken. Iron oxide nanoparticles are synthesised using a common co-precipitation synthesis. Stabilisation was achieved with citrate molecules followed by advanced functionalisation of the nanomaterial with gold achieved via reduction of Au³⁺ (HAuCl₄) to Au⁰ from the citrate ligands. These materials were shown to exhibit remarkable intrinsic heating power when under the influence of an external alternating current magnetic field. Following the potential of iron oxide nanoparticles functionalised with gold for magnetic hyperthermia, multimodal imaging and therapeutic probes were studied. Iron oxide gold nano were analysed as possible Raman enhancer substrates. Finally, iron oxide nanoparticles were synthesised using an organic photoacoustic dye as a stabilising ligand to functionalise the magnetic Fe₃O₄ cores with optical properties. This lead to the novel co-precipitation synthesis of indocyanine green (ICG) and Flamma®774 covalently attached to Fe₃O₄ nanoparticles.

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