Jacobsen, AB;
Bostock, H;
Tankisi, H;
(2019)
Following disease progression in motor neuron disorders with 3 MUNE methods.
Muscle & Nerve
, 59
(1)
pp. 82-87.
10.1002/mus.26304.
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Abstract
INTRODUCTION: The objective of this study was to evaluate a recently developed motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), as a measure of disease progression in amyotrophic lateral sclerosis (ALS) compared to compound muscle action potential (CMAP) amplitude and two traditional MUNE methods. METHODS: ALS patients were evaluated clinically by ALS Functional Rating Scale-Revised (ALSFRS-R). MScan, multiple point stimulation MUNE (MPS) and motor unit number index (MUNIX) were performed in the abductor pollicis brevis (APB) muscle at baseline (27 patients), 4 months (23 patients) and 8 months (16 patients). RESULTS: Of the 5 measures, MScan registered the largest decline (8.7% per month) compared with MPS (3.4%), MUNIX (4.8%), CMAP amplitude (2.0%) and ALSFRS-R (1.9%). Only MScan and ALSFRS-R registered significant decrements over 4 and 8 months. DISCUSSION: MScan may be a sensitive objective tool for quantifying motor unit loss in ALS. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Following disease progression in motor neuron disorders with 3 MUNE methods |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mus.26304 |
| Publisher version: | https://doi.org/10.1002/mus.26304 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | ALS functional rating scale, Amyotrophic lateral sclerosis, MScan, MUNIX, Motor unit number estimation, Multiple point stimulation MUNE, follow-up study, motor unit loss |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053712 |
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