UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database

Ge, S; Beechinor, RJ; Hornik, CP; Standing, JF; Zimmerman, K; Cohen-Wolkowiez, M; Laughon, MM; ... Gonzalez, D; + view all (2018) External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database. Antimicrobial Agents and Chemotherapy 10.1128/AAC.00669-18. (In press). Green open access

[thumbnail of Antimicrob. Agents Chemother.-2018-Ge-AAC.00669-18.pdf]
Preview
Text
Antimicrob. Agents Chemother.-2018-Ge-AAC.00669-18.pdf - Accepted Version

Download (1MB) | Preview

Abstract

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses is to evaluate the feasibility of using a national electronic health record (EHR) database to further externally evaluate this model. Our results suggest that with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.

Type: Article
Title: External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/AAC.00669-18
Publisher version: http://dx.doi.org/10.1128/AAC.00669-18
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: EHR, external evaluation, gentamicin, infant, pharmacokinetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10051743
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item