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Chronic Kidney Disease Risk in African and Caribbean Populations With HIV

Jose, S; Hamzah, L; Jones, R; Williams, D; Winston, A; Burns, FM; Phillips, A; ... Post, FA; + view all (2018) Chronic Kidney Disease Risk in African and Caribbean Populations With HIV. The Journal of Infectious Diseases , 218 (11) pp. 1767-1772. 10.1093/infdis/jiy397. Green open access

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Abstract

We conducted an observational cohort study of end-stage kidney disease (ESKD) in >7,000 African and Caribbean people with HIV in the UK. Using Poisson regression and East Africans as the reference group, the adjusted incidence rate ratio (95% CI) of ESKD was 3.14 (1.26, 7.84) in Southern Africans, 6.35 (2.53, 15.96) in West Africans, and 5.26 (1.91, 14.43) in Caribbeans. Higher CD4 cell count and suppressed HIV replication were associated with reduced risk of ESKD. The risk of ESKD varied among HIV positive people of African heritage, with the highest rates observed in those of West African descent.

Type: Article
Title: Chronic Kidney Disease Risk in African and Caribbean Populations With HIV
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiy397
Publisher version: https://doi.org/10.1093/infdis/jiy397
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
Keywords: Africa; Chronic Kidney Disease; HIV; Caribbean; incidence; HIVAN; End stage kidney disease; West-Africa; region
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10051060
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