Bell, G;
Bogart, LK;
Southern, P;
Olivo, M;
Pankhurst, QA;
Parkin, IP;
(2017)
Enhancing the Magnetic Heating Capacity of Iron Oxide Nanoparticles through Their Postproduction Incorporation into Iron Oxide-Gold Nanocomposites.
European Journal of Inorganic Chemistry
(18)
pp. 2386-2395.
10.1002/ejic.201601432.
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Abstract
Small variations in the synthesis conditions of iron oxide–gold nanocomposites, made in an aqueous medium by a coprecipitation reaction, have a significant effect on the magnetic‐heating properties of the iron oxide nanoparticles. Citric acid coated magnetite/maghemite (Fe3O4/γ‐Fe2O3) nanoparticles were used as a Turkevich‐style reducing agent and added to varying concentrations of HAuCl4 to form iron oxide–gold nanoparticle composites with Fe/Au molar ratios ranging from ca. 5:1 to ca. 300:1. The magnetic‐heating capacities of the products were measured in a high‐frequency alternating field (peak amplitude 6.6 kA/m, frequency 967 kHz), to determine both the specific absorption rates (SARs) and the intrinsic loss powers (ILPs) of the products. The iron oxide (FeOx) precursor presented a moderately high SAR of 33.9 W/gFeOx and an ILP of 0.8 nH m2/kgFeOx, but the iron oxide–gold nanocomposite formed with 0.75 mm HAuCl4 had an almost threefold‐enhanced heating capacity with a SAR of 88.3 W/gFeOx and an ILP of 2.1 nH m2/kgFeOx. This corresponds to an ILP of 3.0 nH m2/kgFe, which is as high as that of any commercially available material to date. This result has implications for the possible postproduction enhancement of the magnetic‐heating capacities of similar iron oxide systems as well as increasing the theranostic potential of such materials through the incorporation of Au nanoparticles, which may act as integrated binding sites for drugs or other beneficial biomolecules.
| Type: | Article |
|---|---|
| Title: | Enhancing the Magnetic Heating Capacity of Iron Oxide Nanoparticles through Their Postproduction Incorporation into Iron Oxide-Gold Nanocomposites |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ejic.201601432 |
| Publisher version: | http://dx.doi.org/10.1002/ejic.201601432 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Inorganic & Nuclear, Chemistry, Iron, Gold, Nanoparticles, Nanostructures, Magnetic properties, Magnetic hyperthermia, COMPOSITE NANOPARTICLES, MOSSBAUER-SPECTROSCOPY, STEM-CELLS, DELIVERY, SHELL, MRI |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10049456 |
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