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The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis"

Hardy, J; (2017) The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis". [Review]. FEBS Journal , 284 (7) pp. 1040-1044. 10.1111/febs.14004. Green open access

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Abstract

The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress was not smooth, however, and many errors were made. In this memoir, I lay out both the progress and the errors.

Type: Article
Title: The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis"
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/febs.14004
Publisher version: http://doi.org/10.1111/febs.14004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, APP, amyloid, genetics, Down syndrome.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10048603
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