Schultz, W;
Stauffer, WR;
Lak, A;
(2017)
The phasic dopamine signal maturing: from reward via behavioural activation to formal economic utility.
Current Opinion in Neurobiology
, 43
pp. 139-148.
10.1016/j.conb.2017.03.013.
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Abstract
The phasic dopamine reward prediction error response is a major brain signal underlying learning, approach and decision making. This dopamine response consists of two components that reflect, initially, stimulus detection from physical impact and, subsequenttly, reward valuation; dopamine activations by punishers reflect physical impact rather than aversiveness. The dopamine reward signal is distinct from earlier reported and recently confirmed phasic changes with behavioural activation. Optogenetic activation of dopamine neurones in monkeys causes value learning and biases economic choices. The dopamine reward signal conforms to formal economic utility and thus constitutes a utility prediction error signal. In these combined ways, the dopamine reward prediction error signal constitutes a potential neuronal substrate for the crucial economic decision variable of utility.
| Type: | Article |
|---|---|
| Title: | The phasic dopamine signal maturing: from reward via behavioural activation to formal economic utility |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.conb.2017.03.013 |
| Publisher version: | https://doi.org/10.1016/j.conb.2017.03.013 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, VENTRAL TEGMENTAL AREA, SUBSTANTIA-NIGRA, PREDICTION-ERROR, NUCLEUS-ACCUMBENS, OPTOGENETIC ACTIVATION, MOTIVATIONAL SIGNALS, STRIATAL NEURONS, AVERSIVE STIMULI, MONKEY MIDBRAIN, GABA NEURONS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048509 |
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