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Imaging biomarkers for the diagnosis of Prion disease.

Canas, LS; Yvernault, BC; Sudre, CH; Vita, ED; Cardoso, MJ; Thornton, JS; Barkhof, F; ... Modat, M; + view all (2018) Imaging biomarkers for the diagnosis of Prion disease. In: Angelini, ED and Landman, BA, (eds.) Medical Imaging 2018: Image Processing. (pp. p. 1057405). SPIE: Houston, Texas, United States. Green open access

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Abstract

Prion diseases are a group of progressive neurodegenerative conditions which cause cognitive impairment and neurological deficits. To date, there is no accurate measure that can be used to diagnose this illness, or to quantify the evolution of symptoms over time. Prion disease, due to its rarity, is in fact commonly mistaken for other types of dementia. A robust tool to diagnose and quantify the progression of the disease is key as it would lead to more appropriately timed clinical trials, and thereby improve patients’ quality of life. The approaches used to study other types of neurodegenerative diseases are not satisfactory to capture the progression of human form of Prion disease. This is due to the large heterogeneity of phenotypes of Prion disease and to the lack of consistent geometrical pattern of disease progression. In this paper, we aim to identify and select imaging biomarkers that are relevant for the diagnostic on Prion disease. We extract features from magnetic resonance imaging data and use genetic and demographic information from a cohort affected by genetic forms of the disease. The proposed framework consists of a multi-modal subjectspecific feature extraction step, followed by a Gaussian Process classifier used to calculate the probability of a subject to be diagnosed with Prion disease. We show that the proposed method improves the characterisation of Prion disease.

Type: Proceedings paper
Title: Imaging biomarkers for the diagnosis of Prion disease.
Event: SPIE Medical Imaging
ISBN-13: 9781510616370
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2293676
Publisher version: http://dx.doi.org/10.1117/12.2293676
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Prion diseases, Creutzfeldt-Jakob disease, Imaging biomarkers, Diagnosis, Prognosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10046780
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