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Effects of Arousal on Mouse Sensory Cortex Depend on Modality

Shimaoka, D; Harris, KD; Carandini, M; (2018) Effects of Arousal on Mouse Sensory Cortex Depend on Modality. Cell Reports , 22 (12) pp. 3160-3167. 10.1016/j.celrep.2018.02.092. Green open access

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Abstract

Changes in arousal modulate the activity of mouse sensory cortex, but studies in different mice and different sensory areas disagree on whether this modulation enhances or suppresses activity. We measured this modulation simultaneously in multiple cortical areas by imaging mice expressing voltage-sensitive fluorescent proteins (VSFP). VSFP imaging estimates local membrane potential across large portions of cortex. We used temporal filters to predict local potential from running speed or from pupil dilation, two measures of arousal. The filters provided good fits and revealed that the effects of arousal depend on modality. In the primary visual cortex (V1) and auditory cortex (Au), arousal caused depolarization followed by hyperpolarization. In the barrel cortex (S1b) and a secondary visual area (LM), it caused only hyperpolarization. In all areas, nonetheless, arousal reduced the phasic responses to trains of sensory stimuli. These results demonstrate diverse effects of arousal across sensory cortex but similar effects on sensory responses.

Type: Article
Title: Effects of Arousal on Mouse Sensory Cortex Depend on Modality
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2018.02.092
Publisher version: http://doi.org/10.1016/j.celrep.2018.02.092
Language: English
Additional information: © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Cerebral cortex, cortical state, locomotion, sensory processing, widefield imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10045900
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