Georgiev, D;
Hamberg, K;
Hariz, M;
Forsgren, L;
Hariz, G-M;
(2017)
Gender differences in Parkinson's disease: A clinical perspective.
Acta Neurologica Scandinavica
, 136
(6)
pp. 570-584.
10.1111/ane.12796.
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Abstract
Available data indicate that there are gender differences in many features of Parkinson's disease (PD). Precise identification of the gender differences is important to tailor treatment, predict outcomes, and meet other individual and social needs in women and men with PD. The aim of this study was to review the available clinical data on gender differences in PD. Original articles and meta‐analyses published between 1990 and 2016 systematically exploring gender differences in PD were reviewed. There is slight male preponderance in incidence and prevalence of PD. PD starts earlier in men. Women tend to be more prone to develop tremor‐dominant PD but are less rigid than men. Motor improvement after deep brain stimulation is equal in both sexes, but women tend to show better improvement in activities of daily living. Furthermore, women with PD show better results on tests for general cognitive abilities, outperform men in verbal cognitive tasks, show more pain symptoms, and score higher on depression scales. It seems, however, that the differences in cognition, mood, and pain perception are not disease specific as similar gender differences can be found in healthy subjects and in other neurological conditions. Despite PD being the most frequently studied movement disorder, studies investigating gender differences in PD are still scarce with most of the studies being cross‐sectional. Good‐quality, prospective, longitudinal studies analyzing gender differences in PD and comparing them to matched healthy controls are needed in order to properly address the issues of gender differences in PD.
| Type: | Article |
|---|---|
| Title: | Gender differences in Parkinson's disease: A clinical perspective |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ane.12796 |
| Publisher version: | http://dx.doi.org/10.1111/ane.12796 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, activities of daily living, gender differences, motor symptoms, non-motor symptoms, Parkinson's disease, quality of life, QUALITY-OF-LIFE, PROGRESSIVE SUPRANUCLEAR PALSY, IMPULSE CONTROL DISORDERS, SLEEP BEHAVIOR DISORDER, MULTIPLE SYSTEM ATROPHY, DEEP BRAIN-STIMULATION, TO-DOOR SURVEY, SEX-DIFFERENCES, NONMOTOR SYMPTOMS, SUBTHALAMIC STIMULATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10045646 |
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