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Optical coherence tomography angiography: a review of current and future clinical applications

Ang, M; Tan, ACS; Cheung, CMG; Keane, PA; Dolz-Marco, R; Sng, CCA; Schmetterer, L; (2018) Optical coherence tomography angiography: a review of current and future clinical applications. Graefe's Archive for Clinical and Experimental Ophthalmology , 256 (2) pp. 237-245. 10.1007/s00417-017-3896-2. Green open access

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Abstract

Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the caveats to the interpretation of images. As current optical coherence tomography angiography systems are optimized for the retina, most studies have focused on interpreting images from conditions such as age related macular degeneration and retinal vascular diseases. However, the interpretation of these optical coherence tomography angiography images should be taken in consideration with other multi-modal imaging to overcome the limitations of each technique. In addition, there are a growing variety of clinical applications for optical coherence tomography angiography imaging in optic nerve head evaluation for glaucoma and optic neuropathies. Further developments in anterior optical coherence tomography angiography have now allowed for evaluation of anterior segment pathology such as glaucoma, ocular surface diseases, corneal vascularisation, and abnormal iris vasculature. Future developments in software could allow for improved segmentation and image resolution with automated measurements and analysis.

Type: Article
Title: Optical coherence tomography angiography: a review of current and future clinical applications
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00417-017-3896-2
Publisher version: https://doi.org/10.1007/s00417-017-3896-2
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Angiography, Cornea, Glaucoma, Optical coherence tomography, Retina, Vascularisation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10042408
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